noface 🇺🇦
On Thu, May 12, 2022 at 12:45 PM, Jessica Creel wrote:
I don't think we should be discouraging this :)
simply eat the female
MTFHRT@groups.io | HRT and brain
HRT and brain
noface 🇺🇦Just another ref for the pile.
https://www.jneurosci.org/content/33/49/19051 Neuroestradiol in the Hypothalamus Contributes to the Regulation of Gonadotropin Releasing Hormone Release Release of gonadotropin releasing hormone (GnRH) from the medial basal hypothalamus (MBH)/median eminence region (S-ME) is essential for normal reproductive function. GnRH release is profoundly regulated by the negative and positive feedback effects of ovarian estradiol (E2). Here we report that neuroestradiol, released in the S-ME, also directly influences GnRH release in ovariectomized female monkeys, in which the ovarian source of E2 is removed. We found that (1) brief infusion of E2 benzoate (EB) to the S-ME rapidly stimulated release of GnRH and E2 in the S-ME of ovariectomized monkeys, (2) electrical stimulation of the MBH resulted in GnRH release as well as E2 release, and (3) direct infusion of an aromatase inhibitor to the S-ME suppressed spontaneous GnRH release as well as the EB-induced release of GnRH and E2. These findings reveal the importance of neuroestradiol as a neurotransmitter in regulation of GnRH release. How circulating ovarian E2 interacts with hypothalamic neuroestrogens in the control of GnRH release remains to be investigated. |
IndigoI just wonder if anyone keep using lena dosage of 0.22ml EEN, cuz on this
my feminisation seem to be okay. Last time I was advised to down the dosage, but am hesitating to. My fogetting habit is still here, do u people think i should really down my dose. I didnt do blood test, and it suck to take a decision here. Dont know hell where this brain issues starts to kick in. As if dysphoria was not enough :( Fck..... On Mon, 19 Sep 2022, 19:29 noface 🇺🇦, <ns.nanika@...> wrote:
Just another ref for the pile. |
LenaI just wonder if anyone keep using lena dosage of 0.22ml EEN, cuz on thisDoctors limit estradiol dosages for two reasons: 1. Doctors' gospels (textbooks and package inserts) say about estrogens: dosage the less the better, stop as soon as possible. Doctors manage to never realise that this mantra was written in the fear of uterine cancer, and that you haven't an uterus. 2. Guidelines say maintan some arbitrarily low estradiol level. Those guidelines were written with the goal to maximize quantity of doctor visits paid by patients and insurance, to force us to pay multiple times to beg for more estradiol. Most transsexual blindly trust doctors and parrot them. :-/ I'm 23 years post-op. I inject myself with the same dosage. I tested a new batch of EEn powder on myself, my blood estradiol level was 1271 pg/ml = 4666 pmol/l 5 days after 0.22 ml injection (weekly). When I forget to inject, I feel worse: some depression, lower libido, lower erogenic zone (nipples) sensitivity. Lena |
noface 🇺🇦On Mon, Sep 19, 2022 at 11:45 AM, Indigo wrote:
Nobody can "advise you" properly, because you are you, everybody's a bit different, and only you know how the different levels feel for you. Take Lena for example. She injects 11mg/wk EEn and feels great. Some people get the same result, some people get a different result. You won't find out how that works for you until you try it. About hesitation - same. Try, and you'll find out, no harm done in the process. Cis women have lousy levels for a part of a month, and mediocre at best for the rest of the month. Endogenous cis E2 production is somewhere around 0.1-0.3mg/day, depending on that time of the month. Works out to about 0.5-2mg/wk, different every week, and it works fine for most of them. This is from Yen & Jaffe's Reproductive Endocrinology, pg.89 btw. I gotta say, I felt more emotionally unstable, and more depressed when I felt depressed, on higher dosages, and it takes a bit of time to adjust to a dosage change, but EEn helps vs EV, and with stuff like EV more frequent dosage helps too when your overall dosage is less. Even when you use EEn, 5mg twice a week will have more effect than 11mg once a week. YMMV of course. But basically, if you feel like something's off and you need a change, make a change and see if it went in the right direction. It's pretty simple. Hundreds of millions of women (menopause) live for decades without E. It's sad obviously. But, compared to that, underdosing DIY E by one of us for a week or two, having the means to correct that, essentially immediately, is sooo non-issue. The only barrier is overexpression of paranoia. Which, yes, we are very prone to. |
Loren AmelangSpironolactone begins blocking testosterone in minutes, and has a half-life of 1.4 hours. For me it was a great way to check whether feeling "head in a vise" angry was due to too much T, or feeling tired and unmotivated was due to already having too little T. Even a single 25 mg tablet made a sudden dramatic difference, and 100 mg at once would pretty much wipe out all my energy - for an hour or two. And then it was gone... (Apparently some people consider 200 mg per day appropriate, so maybe I'm hypersensitive, but the timing of the effects should be similar for everyone.)
Bica and some other antiandrogens build up over days and persist for weeks, so their effect is not useful for this kind of experiment. But much more comfortable if you decide you need less T. |
noface 🇺🇦https://www.nature.com/articles/s41467-022-33884-8
Mapping the effects of pregnancy on resting state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture Abstract While animal studies have demonstrated a unique reproduction-related neuroplasticity, little is known on the effects of pregnancy on the human brain. Here we investigated whether pregnancy is associated with changes to resting state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture using a comprehensive pre-conception cohort study. We show that pregnancy leads to selective and robust changes in neural architecture and neural network organization, which are most pronounced in the Default Mode Network. These neural changes correlated with pregnancy hormones, primarily third-trimester estradiol, while no associations were found with other factors such as osmotic effects, stress and sleep. Furthermore, the changes related to measures of maternal-fetal bonding, nesting behavior and the physiological responsiveness to infant cues, and predicted measures of mother-infant bonding and bonding impairments. These findings suggest there are selective pregnancy-related modifications in brain structure and function that may facilitate peripartum maternal processes of key relevance to the mother-infant dyad. --- The weight map associated with the regression model for estradiol—reflecting the relative contribution of the voxels across the brain—indicates that the regions of strongest neural changes also strongly contribute to this regression (Supplementary Fig. 10). In fact, the weight map shows a remarkable similarity to the map of observed brain changes across pregnancy, suggesting that the levels of estradiol a woman is exposed to during gestation may exert effects across the brain and are likely to contribute to the overall pattern of observed neural changes. Supplementary analyses involving the different sampling points of estradiol measurements across pregnancy were then performed to examine the timing of these effects. These analyses indicated associations with estradiol levels sampled in week 12 as well as a trend for an association with week 24 estradiol levels. Furthermore, associations or trends were observed for estradiol levels extracted from every sampled week of the third trimester (Supplementary Table 51), indicating that especially third-trimester estradiol levels are associated with the observed brain changes. |
LenaI understand its important for the relationship between child and Normal range for third-trimester estradiol is 10,000-40,000 pg/ml =neural changes correlated with pregnancy hormones, primarily 37000-147000 pmol/l. |
noface 🇺🇦On Thu, Dec 15, 2022 at 12:57 PM, Trixie wrote:
There are changes that happen at 3-4mo, which some of us reach by levels. And further changes that most of us won't reach. Pregnancy brain changes do not make women more woman. Plus it's not just just E involved in that. I'm just posting interesting articles on the subject of hormones and brain. |
