noface 🇺🇦More spam. This time newer article. Where is the holy grail that I seek? (Last sentence of abstract)...
https://www.jneurosci.org/content/31/14/5286 Estrogen Shapes Dopamine-Dependent Cognitive Processes: Implications for Women's Health "The prefrontal cortex (PFC) is exquisitely sensitive to its neurochemical environment. Minor fluctuations in cortical dopamine (DA) can profoundly alter working memory, a PFC-dependent cognitive function that supports an array of essential human behaviors. Dopamine's action in the PFC follows an inverted U-shaped curve, where an optimal DA level results in maximal function and insufficient or excessive DA impairs PFC function. In animals, 17β-estradiol (the major estrogen in most mammals, referred to henceforth as estradiol) has been shown to enhance DA activity, yet no human study has adequately addressed whether estradiol's impact on cognition occurs by way of modulating specific neurochemical systems. Here we examined the effects of endogenous fluctuations in estradiol on working memory in healthy young women as a function of baseline PFC DA [indexed by catechol-O-methyltransferase (COMT) Val158Met genotype and, at a finer scale, COMT enzyme activity]. The results demonstrate that estradiol status impacts working memory function and, crucially, the direction of the effect depends on indices of baseline DA. Moreover, consistent with a DA cortical efficiency hypothesis, functional MRI revealed that inferred optimal DA was associated with reduced PFC activity sustained across task blocks and selectively enhanced PFC activity on trials with the greatest demand for cognitive control. The magnitude of PFC activity during high control trials was predictive of an individual's performance. These findings show that although estrogen, considered in isolation, may have unpredictable effects on cognitive performance, its influence is clarified when considered within a larger neuromodulatory framework. Given the clinical prevalence of dopaminergic drugs, understanding the relationship between estrogen and DA is essential for advancing women's health." |
noface 🇺🇦https://pubmed.ncbi.nlm.nih.gov/8818400/
https://pubmed.ncbi.nlm.nih.gov/9784914/ Estrogen control of central neurotransmission: effect on mood, mental state, and memory Sex steroid control of mood, mental state and memory Albeit a little old, and... damn rats. |
noface 🇺🇦Wanted to add more to
https://groups.io/g/MTFHRT/message/3690 And other discussion in that thread. This one is focused on E, but I found it interesting. https://www.nature.com/articles/npp2017157 Hormonal Cycle and Contraceptive Effects on Amygdala and Salience Resting-State Networks in Women with Previous Affective Side Effects on the Pill I want to point out these researchers compared endogenous AND exogenous hormone levels' effect on brain size, connectivity, depression, reactions etc. It would be misleading to directly compare our HRT to their group on BCP, due to synthetics, progesterone, etc., yet conclusions are quite possible. |
